RiffMeter (217 votes)
When Peter Parker is bitten by one of Columbia University's many genetically engineered "super spiders" (now we know what they do with their 6 billion dollar endowment) instead of doing the sensible thing and dying, he transmogrifies into an arachnid, extruding fluids from his spinnerets, leaping about, swinging and twirling just like a spider.
But being a spider naturally puts him on the bad side of Norman Osborn, the charismatic head of OsCorp Industries who manages to find enough time in his day to moonlight as an evil goblin (played by real life evil goblin Willem Dafoe.)
He also finds it difficult to manage his relationship with the beautiful Mary Jane, because, well, he's a freakish wer-spider. His exoskeleton alone makes it literally impossible for him to come out of his shell until it's time to molt – and at that point he's too vulnerable for a relationship. It all makes for the most thrilling arthropod-on-human love and adventure tale ever told in the year 2002!
Joining Mike are Kevin Murphy, Bill Corbett and several harvestmen that live in the corners of the studio. (Yes, we know that harvestmen are not spiders. And, no, theirs is not the most poisonous venom in the world – that's just a myth.)